Hanheng Biotechnology (Shanghai) Co., Ltd.

Application of RNA Synthesis Technology

Synthetic biology is a field of science that deals with the recombination of organisms or parts of biomolecules to obtain new and desired functions. It grew out of the discovery and development of genetic engineering techniques. With the rise of RNA therapeutics as one of the new molecular biology solutions, there has been an interest in conducting research on synthetic systems utilizing the unique properties of RNA molecules. This article provides a brief overview of how RNA synthesis technology can be utilized to create powerful therapeutics.


Diagnostic Tools


Early disease detection is critical for improving patient survival and reducing the burden on the healthcare industry. However, traditional diagnostic tools have limitations such as high production costs and slow speed. The versatility and accelerated development cycle of the RNA-based catalog of sensors and signaling molecules has led to the development of many RNA-based diagnostics for a wide range of diseases, promising to reduce the cost and time of traditional methods.


Improved Cellular CAR-T Therapy


RNA synthesis technology holds great potential for engineered cellular therapies. These therapies are capable of sensing and responding to environmental factors related to location, relevant disease state, and treatment time window. These include circulating cells, implantable cells, and tissue-resident human cells. In this regard, a growing body of research has focused on the use of RNA devices to control engineered T cells, or CAR T cells, to improve the safety and therapeutic efficacy of CAR-T therapies.


RNA Therapeutics and Vaccines


RNA synthesis technology is becoming an increasingly popular area of research as one of the molecular biology solutions. It offers new opportunities for gene therapy against a range of diseases. Vaccines are a new means of immunization that triggers an immune response through the introduction of synthetic RNA encoding specific pathogen antigens. RNA vaccines offer advantages over conventional vaccines in terms of rapid development, scalability, safety, and immunogenicity. In addition, mRNA vaccines have shown promise in cancer treatment by inducing the body's immune response to cancer cells.


Future Perspectives


The combination of RNA synthesis technologies has led to significant therapeutic advances, allowing us to create new treatments and vaccines, and these have the potential to revolutionize the drug and medical industries. While there are still many challenges to overcome in the development of vaccines and RNA therapeutics using synthetic biology, the potential is undeniable. In the coming years, we are sure to witness amazing advances in this field.


Hanbio is a high-tech enterprise focused on gene technology research and application transformation. Our services encompass a wide range of molecular biology solutions, including multiple plasmid vectors designed to meet diverse research needs.