Lentivirus vector is a gene therapy vector developed on the base of HIV-1 (human immunodeficiency virus type 1). Lentivirus vector is a powerful tool for introduction of exogenous genes, with the advantages of wide infection spectrum, effective infection and long-term stable expression of exogenous genes. Now the lentivirus system has been widely used in various cell lines for gene overexpression, RNA interference, microRNA research, as well as in vivo experiments.
Services | Products | Titer | Application |
| Conventional lentivirus | 108TU/ml | Common adherent cells |
High titer lentivirus | 109TU/ml | Difficult to transfect cell lines, such as Suspension Cultured Cells, or used for animal infection |
NO. | Regulation | Vector Name | Prokaryotic Antibiotic | Eukaryotic Antibiotic | Fluorescent Label | Promoter |
LV005 | OE | pHBLV-CMV-MCS-EF1-mCherry-T2A-Puromycin | Ampicillin | Puromycin | mCherry | CMV |
LV006 | OE | pHBLV-CMV-MCS-3flag-EF1-mCherry-T2A-Puromycin | Ampicillin | Puromycin | mCherry | CMV |
LV007 | OE | pHBLV-CMV-MCS-EF1-Puromycin | Ampicillin | Puromycin | NONE | CMV |
LV008 | OE | pHBLV-CMV-MCS-3flag-EF1-Puromycin | Ampicillin | Puromycin | NONE | CMV |
LV011 | OE | pHBLV-CMV-MCS-3flag-EF1-ZsGreen-T2A-Puromycin | Ampicillin | Puromycin | ZsGreen | CMV |
LV012 | OE | pHBLV-CMV-MCS-EF1-ZsGreen-T2A-Puromycin | Ampicillin | Puromycin | ZsGreen | CMV |
LV052 | OE | pHBLV-CMV-MCS-EF1-ZsGreen | Ampicillin | NONE | ZsGreen | CMV |
LV05 | OE | pHBLV-CMV-MCS-3flag-EF1-ZsGreen | Ampicillin | NONE | ZsGreen | CMV |
LV081 | OE | pHBLV-EF1-MCS-CMV-Puromycin | Ampicillin | Puromycin | NONE | EF1 |
LV082 | OE | pHBLV-EF1-MCS-CMV-ZsGreen | Ampicillin | NONE | ZsGreen | EF1 |
LV083 | OE | pHBLV-EF1-MCS-CMV-ZsGreen-T2A-Puromycin | Ampicillin | Puromycin | ZsGreen | EF1 |
LV121 | OE | pHBLV-CMV-MCS-3flag-EF1-Luc-T2A-Puromycin | Ampicillin | Puromycin | Luciferase | CMV |
LV122 | OE | pHBLV-CMV-MCS-EF1-Luc-T2A-Puromycin | Ampicillin | Puromycin | Luciferase | CMV |
LV027 | OE-teton | pHBLV-TetOn-SV40-Puromycin-TRE3GS-MCS | Ampicillin | Puromycin | NONE | TRE3GS |
LV019 | RNAi | pHBLV-U6-MCS-PGK-Puromycin | Ampicillin | Puromycin | NONE | U6 |
LV020 | RNAi | pHBLV-U6-MCS-CMV-ZsGreen | Ampicillin | NONE | ZsGreen | U6 |
LV021 | RNAi | pHBLV-U6-MCS-CMV-ZsGreen-PGK-Puromycin | Ampicillin | Puromycin | ZsGreen | U6 |
LV051 | RNAi | pHBLV-U6-MCS-EF1-mCherry-T2A-Puromycin | Ampicillin | Puromycin | mCherry | U6 |
LV124 | RNAi | pHBLV-U6-MCS-EF1-Luc-T2A-Puromycin | Ampicillin | Puromycin | Luciferase | U6 |
LV144 | RNAi | PHBLV-U6-MCS-CMV-mCherry | Ampicillin | NONE | mCherry | U6 |
LV050 | cas9/gRNA | pHBLV-U6-gRNA-EF1-CAS9-Puromycin | Ampicillin | Puromycin | NONE | U6 |
LV055 | cas9/gRNA | pHBLV-U6-gRNA-EF1-ZsGreen | Ampicillin | NONE | ZsGreen | U6 |
LV133 | cas9/gRNA | pHBLV-U6-gRNA-EF1-ZsGreen-Luc | Ampicillin | NONE | Luciferase | U6 |
Stable integration: Lentiviruses can integrate their genetic material into the host cell's genome, leading to stable and long-term expression of the transgene. This feature is advantageous for sustained gene expression in target cells.
Broad host cell range: Lentiviruses can infect a wide variety of mammalian cells, including both dividing and non-dividing cells, enabling their use in a broad range of cell types and tissues.
Biosafety: Lentiviral vectors can be engineered to be replication-deficient, reducing the risk of uncontrolled viral replication and enhancing their safety for use in research and clinical settings.
Low cytotoxicity: Purification process using ultracentrifugation
Qualified: Strictly follow quality control standards
High titer: The titer can reach up to 109TU/mL
Selection: Available in vectors with a wide variety of promoters, selection markers, and reporters.
Testing Items | Testing Method | Result |
Mycoplasma | PCR | Negative |
Endotoxin | LAL | Qualified |
Bacteria | Culture | Negative |
Fungi | Culture | Negative |
Active Titer | Infection | ≥10^8 TU/ml |
T lymphocyte membrane-decorated epigeneticnanoinducer of interferons for cancerimmunotherapy
(Nature Nanotechnology，IF=39.213，Shanghai Institute of Materia Medica)
The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer
(Molecular Cancer，IF=27.401，ChongQing Medical University)
CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p
(Molecular Cancer，IF=27.401，Nanjing First Hospital, Nanjing Medical University)
Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis
(Molecular Cancer，IF=27.401，Zhejiang Tumor Hospital)
Circular RNA MTCL1 promotes advanced laryngeal squamous cell carcinoma progression by inhibiting C1QBP ubiquitin degradation and mediating beta-catenin activation pathway
(Molecular Cancer，IF=27.401，The First Afliated Hospital of China Medical University)
Extracellular vesicle‐mediated delivery of circDYM alleviates CUS‐induced depressive‐like behaviours
(Journal of Extracellular Vesicles，IF=25.841，Southeast University)
Exosomes derived from osteogenic tumor activate osteoclast differentiation and concurrently inhibit osteogenesis by transferring COL1A1-targeting miRNA-92a-1-5p
(Journal of Extracellular Vesicles，IF=25.841，Xijing Hospital of the Fourth Military Medical University)
TRIB3 Interacts with Beta-catenin and TCF4 to Increase Stem Cell Features ofColorectal Cancer Stem Cells and Tumorigenesis
(GASTROENTEROLOGY，IF=22.682，Peking Union Medical College Hospital)
HACE1-mediated NRF2 activation causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells
(Signal Transduction and Targeted Therapy，IF=18.187，Xi’an Jiaotong University)
TRIB3 reduces CD8+ T cell infiltration and induces immune evasion by repressing the STAT1-CXCL10 axis in colorectal cancer
(Science Translational Medicine，IF=17.956，Institue of Materia Medica Chinese Academy of Medical Science)
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